Comparison of model-based arterial input functions for dynamic contrast-enhanced MRI in tumor bearing rats
نویسندگان
چکیده
منابع مشابه
Toward local arterial input functions in dynamic contrast-enhanced MRI.
PURPOSE To present a method for estimating the local arterial input function (AIF) within a dynamic contrast-enhanced MRI scan, based on the alternating minimization with model (AMM) method. MATERIALS AND METHODS This method clusters a subset of data into representative curves, which are then input to the AMM algorithm to return a parameterized AIF and pharmacokinetic parameters. Computer sim...
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Dynamic Contrast Enhanced MRI (DCE-MRI) is today one of the most popular methods for tumor assessment. Several pharmacokinetic models have been proposed to analyze DCE-MRI. Most of them depend on an accurate arterial input function (AIF). We propose an automatic and versatile method to determine the AIF. The method has two stages, detection and segmentation, incorporating knowledge about artery...
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Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to in...
متن کاملFeasibility of arterial input functions from phase data in T1-weighted dynamic contrast-enhanced MRI
Introduction The accuracy in pharmacokinetic parameters derived from Dynamic Contrast-Enhanced MRI (DCE-MRI) depends strongly on the quality of the arterial input function (AIF). The AIF is challenging to measure accurately for several reasons. For example, T1 needs to be determined with a temporal resolution of about one second and with a spatial resolution high enough to resolve the artery wh...
متن کاملAutomatic determination of arterial input function for estimating tumor microvessel density with dynamic contrast-enhanced MRI in mice model
Introduction Recently, application of DCE-MRI has gained increasing attention for use in drug development in pre-clinical research using mouse models, especially for assessment of angiogenesis for anti-angiogenic drug development (1). In the mouse, the AIF has been manually measured from a large arterial vessel in the center of the left heart ventricle (2). In this case, when the tumor is far f...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2009
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.21959